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Corneal Endothelial Cell Count

Eye Care ≈ ¥20-50 (≈ $3-7) 15 min

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Description

Estimated cost for Corneal Endothelial Cell Count at general public hospitals in China is about ¥15-40, and at Grade 3A hospitals about ¥20-50, varying by hospital tier and region.

Main Uses

Assessing corneal endothelial health prior to intraocular surgery (e.g., cataract, refractive, or corneal transplantation); diagnosing and monitoring endothelial dystrophies (e.g., Fuchs); evaluating corneal decompensation risk; guiding surgical candidacy (e.g., suitability for phakic IOLs or endothelial keratoplasty); postoperative follow-up after corneal or anterior segment procedures; differentiating causes of corneal edema.

Normal Range

Typical corneal endothelial cell density (ECD) in healthy adults aged 20–40 years ranges from 2,500 to 3,500 cells/mm²; declines gradually with age (e.g., ~2,000–2,500 cells/mm² at age 60–70). Coefficient of variation (CV) <30% and percentage of hexagonal cells (hexagonality) >50–60% are considered normal morphometric indicators.

Low Values - Possible Causes

Fuchs endothelial corneal dystrophy, pseudophakic bullous keratopathy (post-cataract surgery), iridocorneal endothelial (ICE) syndrome, congenital hereditary endothelial dystrophy (CHED), chronic intraocular inflammation (e.g., uveitis), prolonged contact lens wear (especially overnight), corneal trauma or surgery (e.g., penetrating keratoplasty, DSEK/DMEK complications)

High Values - Possible Causes

Measurement artifact (e.g., image misalignment, poor focus, specular microscope calibration error), early-stage corneal edema causing apparent cell crowding, post-inflammatory endothelial recovery (rare and transient), technical overestimation due to inclusion of non-endothelial structures (e.g., Descemet’s membrane folds), normal physiological variation in young individuals (<20 years, occasionally up to 4,000–4,500 cells/mm²)

corneal endothelial cell count specular microscopy corneal endothelium assessment

≈ ¥20-50

≈ $3-7

Duration: 15 min